Designing Case-Control Studies
نویسندگان
چکیده
منابع مشابه
Designing case-control studies.
Identification of confounding factors, evaluation of their influence on cause-effect associations, and the introduction of appropriate ways to account for these factors are important considerations in designing case-control studies. This paper presents designs useful for these purposes, after first providing a statistical definition of a confounding factor. Differences in the ability to identif...
متن کاملDesigning case-control studies: decisions about the controls.
The authors quantified, first, the effect of misclassified controls (i.e., individuals who are affected with the disease under study but who are classified as controls) on the ability of a case-control study to detect an association between a disease and a genetic marker, and second, the effect of leaving misclassified controls in the study, as opposed to removing them (thus decreasing sample s...
متن کاملMatched Case-Control Studies
'National Cancer Institute, Biometric Research Branch, DCTD, Executive Plaza North, Room 739, 6130 Executive Boulevard, MSC 7434, Bethesda, Maryland 20892-7434, U.S.A. 2National Cancer Institute, Biometry Research Group, DCP, Executive Plaza North, Room 344, 6130 Executive Boulevard, Bethesda, Maryland 20892, U.S.A. 3F0x Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 1911...
متن کاملCase-control studies.
Case-control studies investigate associations between exposures to risk factors and a condition of interest. Subjects with the condition (cases) are compared to subjects known not to have the condition (controls) with respect to the presence of risk factors in the past. This design is particularly useful when the condition of interest is relatively uncommon. Case-control studies are useful for ...
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Identifying rare genetic variants that drive the onset of disease is challenging, even before considering the additional genetic and environmental influences that likely exist in complex diseases. We recently published a study proposing a rare variant in the NR1H3 gene (p.R415Q, rs61731956) as responsible for the onset of multiple sclerosis (MS) in two multi-incident families (Wang et al., 2016...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1979
ISSN: 0091-6765
DOI: 10.2307/3429012